小泡
聚合物
脂质双层
化学
脂泡
化学工程
纳米技术
材料科学
生物物理学
膜
有机化学
生物化学
生物
工程类
作者
Keith L. Willes,Jasmyn R Genchev,Walter F. Paxton
出处
期刊:Polymers
[MDPI AG]
日期:2020-03-28
卷期号:12 (4): 745-745
被引量:6
标识
DOI:10.3390/polym12040745
摘要
One practical approach towards robust and stable biomimetic platforms is to generate hybrid bilayers that incorporate both lipids and block co-polymer amphiphiles. The currently limited number of reports on the interaction of glass surfaces with hybrid lipid and polymer vesicles-DOPC mixed with amphiphilic poly(ethylene oxide-b-butadiene) (PEO-PBd)-describe substantially different conclusions under very similar conditions (i.e., same pH). In this study, we varied vesicle composition and solution pH in order to generate a broader picture of spontaneous hybrid lipid/polymer vesicle interactions with rigid supports. Using quartz crystal microbalance with dissipation (QCM-D), we followed the interaction of hybrid lipid-polymer vesicles with borosilicate glass as a function of pH. We found pH-dependent adsorption/fusion of hybrid vesicles that accounts for some of the contradictory results observed in previous studies. Our results show that the formation of hybrid lipid-polymer bilayers is highly pH dependent and indicate that the interaction between glass surfaces and hybrid DOPC/PEO-PBd can be tuned with pH.
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