芳基
阿托品
立体中心
化学
邻接
环加成
蒽
立体化学
有机化学
对映选择合成
催化作用
作者
Yuanyuan Wei,Guillaume Dauvergne,Jean Rodríguez,Yoann Coquerel
摘要
Enantioenriched aryne atropisomers having a biaryl stereogenic axis vicinal to the reactive triple bond are demonstrated to exist. These reaction intermediates are easily produced in situ and can undergo the standard aryne cycloaddition chemistry in an enantiospecific manner. Notably, the aryne atropisomers herein have allowed the practical syntheses of a small nanographene as well as some triptycene and anthracene derivatives that embed stereogenic axes of controlled absolute configurations.
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