Cardiovascular research developments • Latest insights • Heart failure • Atrial fibrillation Over the last years, the medical faculties in Go ¨ttingen and Heidelberg have gained important insights into the pathophysiology of heart failure (HF), cardiomyopathies, and cardiac arrhythmias (Figure 1).The scientific interest of researchers at both universities has led to fruitful interactions and collaborations to elucidate cardiovascular pathophysiological mechanisms.Until today, cardiovascular research at both universities has involved interactions between basic science, clinical, and especially translational aspects.Here, we aim to summarize some of the latest cardiovascular research developments from both institutions.