甲基转移酶
核糖核酸
化学
RNA甲基化
甲基化
计算生物学
非编码RNA
基因表达
遗传密码
基因
生物化学
生物
作者
Gan‐Qiang Lai,Lingsha Zhou,Cai‐Guang Yang
标识
DOI:10.1002/cjoc.201900490
摘要
The m 6 A‐RNA modification is a dynamic and reversible process, which has emerged as a new RNA code for the regulation of gene expression. The functional network of methyltransferases (writers), demethylases (erasers), and binding proteins (readers) modulate the level of m 6 A modification. Dysfunction of RNA methylation has been associated with various fundamental biological processes and human diseases. Herein, we briefly introduce an understanding‐enabled manipulation on m 6 A‐RNA modification with an emphasis on the use of small‐molecule intervention.
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