缘上回
医学
功能磁共振成像
内科学
脑回
额下回
神经科学
心脏病学
心理学
作者
Lijuan Wang,Zhifen Liu,Xiaohua Cao,Ning Sun,Chunxia Yang
出处
期刊:Chin J Psychiatry
日期:2016-12-05
卷期号:49 (6): 399-403
标识
DOI:10.3760/cma.j.issn.1006-7884.2016.06.008
摘要
Objective
To explore the influence of a polymorphism of protein tyrosine phosphatase receptor type R (PTPRR) gene rs1513105 on abnormal brain activities in resting-state patients with major depressive disorder (MDD) using the gene-imaging technology.
Methods
54 MDD and 43 gender-, age-, and education-matched controls received fMRI scans and genotyping to identify the main effect of disease status, genotypes and their interaction in MDD.
Results
The results of 2×2 ANOVA showed increased ReHo in left superior temporal gyrus (t= 4.208 2), right supramarginal gyrus(t= 3.027 1), left superior parietal gyrus (t= 3.212 2) were in patients than controls. The carriers with TT genotype showed increased ReHo in left inferior parietal gyrus (t=3.129 0), left postcentral gyrus (t= 3.263 3) and reduced ReHo in right caudate nucleus (t= -3.443 4), right inferior frontal gyrus, opercular part (t= -3.444 5), right cerebelum (t= -3.079 3) than G allele carriers(P<0.05). The patients showed increased ReHo in right inferior temporal gyrus (t= 3.560 2), right inferior frontal gyrus, triangular part (t= 3.296 1) and reduced ReHo in left superior temporal gyrus (t= -4.354 3), left precuneus(t= -4.026 7), left superior frontal gyrus(t= -3.656 0),left inferior occipital gyrus (t= -3.805 4), right supramarginal gyrus (t= -3.433 2) than controls, comparing G allele carriers with TT genotype carriers. Reduced ReHo in left inferior occipital gyrus was positively correlated with cognitive (r=0.323, P= 0.017) and sleep disturbance (r=0.318, P= 0.019), Reduced ReHo in right supramarginal gyrus was positively correlated with cognitive disturbance (r=0.273, P= 0.046).
Conclusion
The interaction between PTPRR gene polymorphism and MDD may contribute to the change of resting-state function of some depression-related brain region, and might be involved in the pathogenesis of MDD.
Key words:
Depressive disorder; Magnetic resonance imaging; Protein-tyrosine-phosphatase; Genes; Regional homogeneity
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