Trifluoroacetylation of 2‐Methyl‐ and 2‐Ethylchromones: A Convenient Access to 2‐Trifluoroacetonyl Chromones

Abstract A simple and efficient method for the synthesis of 2‐(3,3,3‐trifluoroacetonyl) chromones and isoflavones has been developed. This method involves an initial in situ generation of the vinyl ethers from 2‐methyl‐ or 2‐ethylchromones/isoflavones and their subsequent acylation with trifluoroacetic anhydride in the presence of CF 3 COOK. This pathway provides convenient access to novel fluorinated analogs of naturally occurring chromones.