Objective To explore the technical metheds in application and it's diagnosis value for solitary pulmonary nodule. Methods Ninety-eight patients with pathologically or clinically diagnosed solitary pulmonary nodule underwent dynamic enhanced CT scan, the delay time were 30s, 90s, 180s, 300s, 480s. According to dynamic enhanced examination, the enhanced value and ratio of nodule-to-aorta peak enhancement were calculated, the characteristics of time-density curve( TDC) of the three groups nodule were studied. Results The enhanced value and nodule-to-aorta peak enhancement ratios of malignant and inflammatory pulmonary nodule were higher than that of benign group respectively(p=0.000). But the difference between malignant group and active inflammatory group had no statistical significance. From the characteristics of TDC shape deriving from dynamic enhanced CT scanning, the malignant nodule could be differentiated from inflammatory and benign nodule. Conclusion Dynamic enhanced CT scan offers to the good diagnosis value for solitary pulmonary nodule.