EXPRESSION OF CTX-II OF THE SYNOVIAL FLUID IN KNEE JOINT OSTEOARTHRITIS AND ITS CLINICAL SIGNIFICANCE

Objective To examine Expression of CTX-II of the synovial fluid in knee joint osteoarthritis(KOA) and its clinical significance.Methods Eighty patients diagnosised with KOA and another twenty patients diagnosised without osteoarthritis were also selected.These eighty patients with KOA were classified into four groups:moderate,severe,very severe,extremely severe.The CTX-II level in the synovial fluid were measured by Enzyme Linked Immunossassy Assay(ELISA).Results ①The CTX-II level of KOA patients were higher than control group(p0.05);②The CTX-II level of KOA patients increased with the aggravation of degeneration(extremely severevery severeseveremoderate);③There was significant correlation between the expression of CTX-II and the severity of KOA(p0.05).Conclusions The CTX-II level in the synovial fluid increased with the aggravation of degeneration,which can be used to predict the development of KOA.