The Screening of the Buffer Solution on Povidone-iodine Gel and Its Stability Studies

Objective Screen for the best buffer solution to improve the stability of the povidone-iodine gel.Method The influences of non-buffer and different buffers(phosphate buffer solution and Citrate buffer solution)on the stability of povidone-iodine gel were investigated by accelerated tests at 30 ℃and 40 ℃.Result After 6 months of accelerated tests,each of the parameters of povidone-iodine gel Ⅴ with Citrate buffer solution(0.2 mol/L) is eligible,the others are not eligible with the sharp decrease in pH values and the content of available iodine.Conclusion Citrate buffer solution is the best solution for the preparation of povidone-iodine gel and the solution is helpful to improve the stability of the gel.