SARS-Related coronavirus and its relationship with animal coronaviruses

The sequences of spike glycoprotein genes of six human coronavirus strains,five avian infectious bronchitis virus strains,four murine hepatitis virus strains,seven bovine coronavirus strains,two feline coronavirus strains,nine porcine coronavirus strains (epidemic diarrhea virus,transmissible gastroenteritis virus),four canine coronavirus strains and five SARS coronavirus strains were compared by software DNAstar.It is shown that the sequence consensus of human coronavirus spike glycoprotein genes is 27.2%～99.5%;that of avian infectious bronchitis viruses is 81.5%～100%;of feline coronavirus strains is 79.5%～89.6%;of bovine coronavirus strains is 97.7%～100%;of canine coronavirus strains is 64.9%～98.8%;of SARS-related coronavirus is 99.9%～100%.The sequence consensus of spike glycoprotein genes of SARS coronavirus strains compared with forty-two other coronavirus strains is lower than 30.8%,which indicates that SARS-related coronavirus might not evolve from the other kind of viruses,but it is a new kind of virus that humankind has never touched before.