The effect of inhibition on lipid peroxides of Orobanche cumana Wallr. was investigated. It was showed that lipid peroxides in livers of mice could be inhibited by ethyl acetate and n butanol extracts from Orobanche cumana Wallr.. Orobanchoside and verbascoside isolated from the ethyl acetate extract were regarded as anti lipid peroxidation bioactive substances. The IC 50 of the two compounds were (1 1± 0 2)μg/mL and (1 1± 0 3)μg/mL respectively. Orobanche cumana Wallr. can be developed as a new medicinal resource.