In order to provide experimenal basis for a better choose of spray-dried Powder of shaogan granules with damp-proofing excipients and producing condition.Under 25 ℃,75% relative humidity,compatibility spray-dried powder and others excipients,inspecting its moisture absorption percentage,critical relative humidity.Result show that the optimized damp-proofing excipient is latcose.The ingredient ratio of spray-dried powder to excipient is 4:1.