氰化
苯甲腈
化学
二甲基乙酰胺
亚铁氰化钾
甲苯
衍生工具(金融)
钯
催化作用
芳基
溴化物
溶剂
组合化学
有机化学
经济
烷基
金融经济学
作者
Masayuki Utsugi,Hiroki Ozawa,Eiji Toyofuku,Masanori Hatsuda
摘要
A practical and reproducible synthetic method for the preparation of a benzonitrile derivative (1) from an aryl bromide (2) via Pd-catalyzed cyanation was established with dimethylacetamide (DMAc)–toluene as a mixed solvent. Optimization was examined by a design of experiments (DoE) technique to enhance reaction conversion and reduce the dimeric impurity 3, and desired benzonitrile derivative 1 was successfully obtained in high yields with excellent quality control on a 117 kg scale.
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