CD8型
川地69
生物
细胞毒性T细胞
分子生物学
抗原
白细胞介素2受体
细胞生物学
免疫学
T细胞
免疫系统
生物化学
体外
作者
Simone L. Park,Laura K. Mackay,Thomas Gebhardt
摘要
Tissue‐resident memory T (T RM ) cells occupy peripheral and lymphoid tissues where they confer protection against local infection. While epithelial CD8 + T RM cells coexpress CD69 and CD103, CD103 − memory cells have been described in various organs and are often presumed non‐recirculating based on their expression of CD69. We found that both CD69 + CD103 + and CD69 + CD103 − memory cells populated the thymus upon transfer of CD8 + effector T cells into uninfected recipients. Transcriptionally and phenotypically, CD103 + thymic cells resembled non‐lymphoid T RM cells, whereas CD69 + CD103 − cells displayed a profile that was more closely related to recirculating cells. Although CD69 was required for optimal CD103 + T RM formation, its expression alone did not identify permanently resident cells, as CD69 + CD103 − cells disappeared from the thymus following antibody‐mediated depletion of recirculating cells. Our findings highlight a distinct migration potential of phenotypically divergent thymic CD8 + memory T cells and emphasise the inadequacy of CD69 as a marker of tissue residency.
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