Effect of E.coli on intestinal mucosal immunity-associated cells of rabbits was studied,and the curative effect was compared by intestinal mucosal immunity,forty rabbits were randomly divided into four groups.At different times mucosal immunity-associated cells were observed after injection of E.coli by abdominal cavity.The results showed that the number of mucosal immunity-associated cells was increased after intraperitoneal injection of bacilli,intestinal mucosal immunity was stimulated.There were no differences among cidomycin,lactolin and control groups or cidomycin and lactolin groups,better treatment effect was made.