To observe pathological changes of liver induced by 70 g/L carbon tetrachloride and alcohol in mice,and to make an animal model.25 Kunming mice were randomly devided into 2 groups.The samples of livers were taken after four weeks,at the same time,the levels of AST ALT SOD in sera were examined.The chronic liver injury model in mice clould be induced by 70 g/L CCl4 and 100 mL/L alcoho.