Objective To evaluate the clinical value of high-frequency ultrasound in diagnosis and differential diagnosis of breast diseases.Methods A retrospective analysis was performed on 54 patients with beast masses.The patients were examined by using high-frequency ultrasound.Results In 32 patients with malignant masses,micro-calcification was found in 30 cases(93.75%),and coarse-calcification was discovered in 2 patients(6.25%).In 22 patients with benign masses,micro-calcification was found in 4 cases(18.18%),coarse-calcification in 13 cases(59.09%) and curved-calcification in 5 cases(22.73%).Conclusions High-frequency ultrasound can identify breast micro-calcifications,especially malignant lesions.Therefore,the detection of micro-calcifications in breast masses by using high-frequency ultrasound technique has a great value in diagnosis and differential diagnosis of breast diseases.