补体系统
免疫学
发病机制
细胞凋亡
补语(音乐)
经典补体途径
红斑狼疮
系统性红斑狼疮
病因学
医学
生物
免疫系统
抗体
疾病
病理
遗传学
表型
基因
互补
作者
Chau‐Ching Liu,J Navrátil,Janice M Sabatine,Joseph M. Ahearn
出处
期刊:KARGER eBooks
[S. Karger AG]
日期:2003-01-01
卷期号:: 49-86
被引量:21
摘要
Deficiencies in the classical pathway of the complement system have been implicated in the etiology and pathogenesis of systemic lupus erythematosus (SLE) for several decades. Recent advances have suggested that this link is due to a critical role of complement in the recognition and clearance of the cellular remnants of apoptosis. In this review, we summarize the role of apoptosis in generation of an autoimmune response, and we integrate recent advances that link apoptosis, complement activation and the etiopathogenesis of SLE.
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