Zebrafish Development: High‐Throughput Test Systems to Assess Developmental Toxicity

Because of its developmental concordance, ease of handling and rapid development, the small teleost, zebrafish (Danio rerio), is frequently promoted as a vertebrate model for medium-throughput developmental screens. This present chapter discusses zebrafish as a an alternative animal model for screening for developmental toxicity and the different approaches that are taken by various investigators. Even though the zebrafish model is showing promise, there are still some aspects of the approach that may limit its usefulness for predictive toxicity.