Gold‐Catalyzed Dehydrogenative Cycloisomerization of 1,4‐Enyne Esters to 3,5‐Disubstituted Phenol Derivatives

Abstract A method to prepare synthetically important 3,5‐disubstituted phenol derivatives that relies on the sequential gold(I)‐catalyzed dehydrogenative cycloisomerization of 1,4‐enyne esters in the presence of 2,3‐dichloro‐5,6‐dicyanobenzoquinone (DDQ) or N ‐fluorobenzenesulfonimide (NFSI) is described. The synthetic versatility of the methodology was exemplified by a gram‐scale reaction of one example, the ease to realize subsequent functional transformations of an adduct, and the application of the method to the synthesis of the bioactive molecule LUF5771. magnified image