阿米替林
巴科帕蒙尼里酒店
药代动力学
药理学
最大值
生物利用度
医学
分配量
口服
草本植物
传统医学
草药
作者
Fowad Khurshid,G. Jeyabalan,Habibullah Khalilullah,Mohammed Shivli Nomani,Mudassar Shahid,M.R. Faridatul Ain,Mohammad Sultan Alsultan
出处
期刊:Brazilian Journal of Pharmaceutical Sciences
[University of São Paulo]
日期:2018-03-03
卷期号:53 (4)
被引量:4
标识
DOI:10.1590/s2175-97902017000417072
摘要
Interactions between herbs and drugs may increase or decrease the pharmacological or toxicological effects of either component. Experimental data on the pharmacokinetic interactions between herbal products and drugs are limited. This study attempted to investigate the effect of Bacopa monnieri Linn. (Brahmi) formulation on the pharmacokinetics of amitriptyline in rats. In this study, rats were randomly divided into two groups (n = 6 each) which were served as a control (amitriptyline alone) and treatment group (amitriptyline with B. monnieri), respectively. Rats in the treatment group received B. monnieri (31 mg/kg/day) whereas the control group received normal saline by oral gavage for seven days before a single intragastric administration of 25 mg/kg amitriptyline. Plasma concentrations of amitriptyline were measured up to 24 h after its administration by a developed and validated high-performance liquid chromatography method. Pretreatment with B. monnieri produced a significant increase in the maximum plasma concentration (Cmax), area under the curve (AUC0-t) and elimination half-life (t1/2) of amitriptyline by 16.8%, 26.5%, and 15.5%, respectively, compared to amitriptyline alone. Moreover, oral clearance and volume of distribution (Vss) were decreased by 26.2% and 15.5% respectively. This study concluded that B.monnieri significantly enhanced the oral bioavailability of amitriptyline in rats.
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