胰岛素抵抗
医学
糖化血红素
荟萃分析
内科学
2型糖尿病
糖尿病
体质指数
胰岛素
2型糖尿病
稳态模型评估
置信区间
血糖
严格标准化平均差
内分泌学
作者
A. Sampath Kumar,Arun G Maiya,BA Shastry,K Vaishali,Nirmala Ravishankar,Animesh Hazari,Shubha Gundmi,Radhika Jadhav
出处
期刊:Annals of Physical and Rehabilitation Medicine
日期:2019-03-01
卷期号:62 (2): 98-103
被引量:214
标识
DOI:10.1016/j.rehab.2018.11.001
摘要
Insulin resistance is a determining factor in the pathophysiology of type 2 diabetes mellitus (T2DM). Exercise is known to improve insulin resistance, but a systematic review of the literature is lacking. This systematic review and meta-analysis focused on identifying evidence for the effectiveness of a structured exercise intervention program for insulin resistance in T2DM. We searched MEDLINE via PubMed, CINHAL, Scopus and Web of Science, and the Cochrane Central Register of Controlled Trials for reports of studies on fasting insulin, homeostatic model assessment for insulin resistance (Homa-IR), fasting blood sugar, glycated hemoglobin and body mass index in patients with T2DM and healthy controls that were published between 1990 and 2017. Data are reported as the standardized mean difference or mean difference with 95% confidence intervals (CIs). Among 2242 records retrieved, only 11 full-text articles were available for meta-analysis. Data for 846 participants were analyzed, 440 in the intervention group, and 406 in the control group. The mean difference for fasting insulin level was −1.64 (95% CI; −3.38 to 0.10), Homa-Ir 0.14 (−1.48 to 1.76), fasting blood sugar −5.12 (−7.78 to −2.45), hemoglobin A1c 0.63 (−0.82 to 2.08) and body mass index −0.36 (−1.51 to 0.79). The evidence highlights the effectiveness of a structured exercise intervention program for insulin resistance in T2DM with a moderate level 2 of evidence.
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