杰纳斯
材料科学
杰纳斯粒子
纳米技术
复合数
多孔性
磷灰石
化学工程
生物医学工程
复合材料
医学
工程类
作者
Lei Miao,Xue Qu,Huan Liu,Yi Liu,Shijia Wang,Shang Wang,William E. Bentley,Gregory F. Payne,Changsheng Liu
标识
DOI:10.1002/adfm.201900065
摘要
Abstract Janus films with controlled pore structures can be particularly important in diverse applications. There remains a challenge for simple, rapid, and scalable fabrication methods to control Janus balance (JB) including the thickness of the individual face as well as porosity and pore size. Here the electrofabrication of a porous Janus film with controlled Janus balance from aminopolysaccharide chitosan under the salt effect is reported. Sequential deposition of chitosan under programmable salt environment and electrochemical conditions enables construction of Janus films with precisely controlled Janus balance. Bioactive partially soluble calcium phosphate (CaP) salts can also generate porous structure in Janus film. It is specifically reported that a chitosan/hydroxyl apatite (HAp) composite Janus film can serve as an effective scaffold for guided bone regeneration. The dense layer functions to provide mechanical support and serves as a barrier for fibrous connective tissue penetration. The porous composite layer functions to provide the microenvironment for osteogenesis. In vivo studies using a rat calvarial defect model confirm the beneficial features of this Janus composite for guided bone regeneration. These results suggest the potential of electrofabrication as a simple and scalable platform technology to tune the self‐organization of soft matter for a range of emerging applications.
科研通智能强力驱动
Strongly Powered by AbleSci AI