化学
串联
二酮
甲烷
药物化学
有机化学
复合材料
材料科学
作者
Mutsumi Sada,Seijiro Matsubara
摘要
Treatment of an γ-acyloxy-α,β-unsaturated ketone with bis(iodozincio)methane leads to a novel tandem reaction consisting of three steps: (1) 1,4-addition of the dizinc reagent to the enone, which affords the corresponding zinc enolate of the β-zinciomethylated ketone; (2) intramolecular nucleophilic attack by the enolate on the ester group; and (3) Grob-type fragmentation of the adduct, accompanied by elimination of the zinc alkoxide of allyl alcohol. The overall reaction gives 1,3-diketones efficiently.
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