Recent progress in the synthesis of diclofenac based NSAIDs analogs/derivatives

Non-steroidal anti-inflammatory drugs (NSAIDs) are known for inhibition of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Diclofenac and its analogs, having phenylacetic acid moiety, are important NSAIDs. In this review article, various methodologies developed after 90 s for the synthesis of various analogs/derivatives of diclofenac sodium have been discussed and summarized.