Asymmetric Synthesis of Spirooxazolidinone Oxindoles by the Thiourea‐Catalyzed Aldol Reaction of 2‐Isocyanatomalonate Diesters

Abstract A tertiary amino‐thiourea catalyzed asymmetric aldol reaction between 2‐isocyanatomalonate esters and isatins has been achieved. Optical active spirooxazolidinone oxindole derivatives could be obtained with excellent yields (80%–96%) and enantioselectivities (67%–99% ee) under mild conditions, providing an updated example to apply isatins as the electrophile in the asymmetric aldol reaction with 2‐isocyanatomalonate esters. magnified image