Meta-analysis of Xiaochaihu Decoction in the Treatment of Cancer Fever

Objective: To explore the safety and effectiveness of Xiaochaihu Decoction in the treatment of cancer fever. Methods: The randomized controlled trials (RCTs) of Xiaochaihu Decoction or modified Xiaochaihu Decoction in the treatment of cancer fever were retrieved from CNKI and Wanfang databases. The results of the included literatures were analyzed by revman5.3 software to study the clinical efficacy of Xiaochaihu Decoction or modified Xiaochaihu Decoction in the treatment of cancer fever, Meta- analysis software was used to analyze the mechanism of Xiaochaihu Decoction in the treatment of cancer fever. Results: The final results showed that a total of 16 RCTs were included. Meta-analysis showed that the significant efficiency [or = 2.31, 95% CI (1.81,2.95), z = 6.75, P < 0.00001] and total effective rate [or = 3.29, 95% CI (2.43,4.46), z = 7.70, P < 0.00001] of Xiaochaihu Decoction or Xiaochaihu Decoction in the treatment of cancer fever were significantly better than those of the control group. Conclusion: it has been proved that Xiaochaihu Decoction or modified Xiaochaihu Decoction is effective in treating cancer fever, which fully reflects the comprehensive advantages of traditional Chinese medicine in regulating physiological homeostasis.