嵌合抗原受体
效应器
癌症研究
实体瘤
免疫系统
医学
免疫疗法
免疫学
生物信息学
生物
内科学
癌症
作者
Pooria Safarzadeh Kozani,Pouya Safarzadeh Kozani,Fatemeh Rahbarizadeh
标识
DOI:10.1080/07388551.2021.1988509
摘要
Chimeric antigen receptor T cell (CAR-T) therapy has been recognized as one of the most prosperous treatment options against certain blood-based malignancies. However, the same clinical and commercial success have been out of range in the case of solid tumors. The main contributing factor in this regard is the hostile environment the tumor cells impose that results in the exhaustion of immune effector cells alongside the abrogation of their infiltration capacity. The discovery of the underlying mechanisms and the development of reliable counterstrategies to overcome the inaccessibility of CAR-Ts to their target cells might correlate with encouraging clinical outcomes in advanced solid tumors. Here, we highlight the successive physical and metabolic barriers that systemically administered CAR-Ts face on their journey toward their target cells. Moreover, we propose meticulously-devised countertactics and combination therapies that can be applied to maximize the therapeutic benefits of CAR-T therapies against solid tumors.
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