A Lesion Microenvironment‐Responsive Fungicide Nanoplatform for Crop Disease Prevention and Control

Abstract Controlled fungicide delivery in response to the specific microenvironment produced by fungal pathogens is an advisable strategy to improve the efficacy of fungicides. Herein, the authors construct a smart fungicide nanoplatform, using mesoporous silica nanoparticles (MSNs) as nanocarriers loaded with eugenol (EU) and Ag + coordinated polydopamine (Ag + ‐PDA) as a coating to form Ag + ‐PDA@MSNs‐EU NPs for Botrytis cinerea ( B. cinerea ) control. As a botanical fungicide, EU offers an eco‐friendly alternative to synthetic fungicides and can upregulate several defense‐related genes in the tomato plant. The Ag + ‐PDA coating can lock the EU inside the nanocarriers and respond to the oxalic acid produced by B. cinerea to corelease the loaded EU and Ag + . The results demonstrate that Ag + ‐PDA@MSNs‐EU NPs can effectively inhibit the mycelial growth of B. cinerea on detached and potted tomato leaves. The construction of such a smart fungicide nanoplatform provides new guidance to design controlled fungicides release systems, which can respond to the microenvironment associated with plant pathogen to realize fungus control.