生物
细胞生物学
植物病毒
病毒
病毒复制
病毒学
植物免疫
基因
病毒进入
黄瓜花叶病毒
传输(电信)
胚状病毒
双子病毒科
病毒病机
病毒蛋白
烟草
作者
Yaling Zhao,Xue Cao,Weihua Zhong,Shunkang Zhou,Zhanbiao Li,Hong An,Xiahua Liu,Ruifeng Wu,Surakshya Bohora,Yan Wu,Zhenyi Liang,Jiahao Chen,Xin Yang,Guohui Zhou,Tong Zhang
标识
DOI:10.1016/j.molp.2022.01.006
摘要
Abstract
Arthropod-borne viruses cause serious threats to human health and global agriculture by rapidly spreading via insect vectors. Southern rice black-streaked dwarf virus (SRBSDV) is the most damaging rice-infecting virus frequently transmitted by planthopper. However, the molecular mechanism underlying its propagation in the host and epidemic in the field is largely unknown. Here, we showed that SRBSDV-encoded P6 protein is a key effector regulating rice ethylene signaling to coordinate viral infection and transmission. In the early SRBSDV infection stage, P6 interacts with OsRTH2 in the cytoplasm to activate ethylene signaling and enhance SRBSDV proliferation, which also repels the insect vector to reduce infestation. In the late infection phase, P6 enters the nucleus where it interacts with OsEIL2, a key transcription factor of ethylene signaling. P6-OsEIL2 interaction tunes down ethylene signaling by preventing the dimerization of OsEIL2, which facilitates viral transmission by attracting insect vector. These findings unveil a novel molecular mechanism by which arbovirus orchestrates host defense system to benefit its infection and transmission.
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