Cyber-Physical Systems (CPS) are fundamental in Industry 4.0 and manufacturing research communities, and research and technologies organizations (RTO) are keen to implement CPS laboratories. Due to the strong investment in these laboratories, it is unfordable the investment in CPS laboratories. This paper proposes a CPS architecture based on Open Design (an open-source approach for hardware and software), and the implementation of the laboratory created as an open-source and truly low-cost solution, designated as Open Science Lab for Manufacturing (OSLab4Man), addressing the reproducibility and replicability (R&R) practices for manufacturing research laboratories. An open-source and truly low-cost solution of the OSLab4Man and the bill of materials (BOM) of the physical components and some alternative components open-source and/or low-cost is presented, that enables a ubiquitous manufacturing system.