纳米纤维
丝胶
静电纺丝
哈卡特
伤口愈合
材料科学
壳聚糖
极限抗拉强度
药物输送
丝绸
生物医学工程
化学
体外
纳米技术
医学
复合材料
外科
聚合物
有机化学
生物化学
作者
Sneha Anand,Prashant Pandey,M. Yasmin Begum,Kumarappan Chidambaram,Dilip Kumar Arya,Ravi Kr. Gupta,Ruchi Sankhwar,Shweta Jaiswal,S.S. Thakur,P.S. Rajinikanth
出处
期刊:Pharmaceuticals
[Multidisciplinary Digital Publishing Institute]
日期:2022-02-28
卷期号:15 (3): 302-302
被引量:56
摘要
Diabetic foot ulceration is the most distressing complication of diabetes having no standard therapy. Nanofibers are an emerging and versatile nanotechnology-based drug-delivery system with unique wound-healing properties. This study aimed to prepare and evaluate silk-sericin based hybrid nanofibrous mats for diabetic foot ulcer. The nanofibrous mats were prepared by electrospinning using silk sericin mixed with different proportions of polycaprolactone (PCL) and cellulose acetate (CA) loaded with ferulic acid (FA). The in vitro characterizations, such as surface morphology, mechanical properties, swelling behavior, biodegradability, scanning electron microscopy, and drug release were carried out. The SEM images indicated that nanofibers formed with varied diameters, ranging from 100 to 250 nm, and their tensile strength was found to range from 7 to 15 MPa. In vitro release demonstrated that the nanofibers sustained FA release over an extended time of period. In vitro cytotoxicity showed that the nanofibers possessed a lower cytotoxicity in HaCaT cells. The in vivo wound-healing studies demonstrated an excellent wound-healing efficiency of the nanofibers in diabetic rats. Furthermore, the histopathological studies showed the nanofibers' ability to restore the skin's normal structure. Therefore, it was concluded that the prepared silk-sericin-based hybrid nanofibers loaded with FA could be a promising drug-delivery platform for the effective treatment of diabetic foot ulcers.
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