Hyperechoic Renal Masses: Differentiation of Angiomyolipomas from Renal Cell Carcinomas using Tumor Size and Ultrasound Radiomics

A retrospective single-center study was performed to assess the performance of ultrasound image-based texture analysis in differentiating angiomyolipoma (AML) from renal cell carcinoma (RCC) on incidental hyperechoic renal lesions. Ultrasound reports of patients from 2012 to 2017 were queried, and those with a hyperechoic renal mass <5 cm in diameter with further imaging characterization and/or pathological correlation were included. Quantitative texture analysis was performed using a model including 18 texture features. Univariate logistic regression was used to identify texture variables differing significantly between AML and RCC, and the performance of the model was measured using the area under the receiver operating characteristic (ROC) curve. One hundred thirty hyperechoic renal masses in 127 patients characterized as RCCs (25 [19%]) and AMLs (105 [81%]) were included. Size (odds ratio [OR] = 0.12, 95% confidence interval [CI]: 0.04-0.43, p < 0.001) and 4 of 18 texture features, including entropy (OR = 0.09, 95% CI: 0.01-0.81, p = 0.03), gray-level non-uniformity (OR = 0.12, 95% CI: 0.02-0.72, p = 0.02), long-run emphasis (OR = 0.49, 95% CI: 0.27-0.91, p = 0.02) and run-length non-uniformity (OR = 2.18, 95% CI: 1.14-4.16, p = 0.02) were able to differentiate AMLs from RCCs. The area under the ROC curve for the performance of the model, including texture features and size, was 0.945 (p < 0.001). Ultrasound image-based textural analysis enables differentiation of hyperechoic RCCs from AMLs with high accuracy, which improves further when combined with tumor size.