斑秃
医学
免疫疗法
皮肤病科
临床试验
临床意义
内科学
癌症
作者
Kathryn Weise,Lars Kretzschmar,Savio John,Henning Hamm
出处
期刊:Dermatology
[S. Karger AG]
日期:1996-01-01
卷期号:192 (2): 129-133
被引量:62
摘要
Topical immunotherapy of alopecia areata (AA) is an effective but time-consuming treatment with unknown long-term risks.The purpose of this study was to identify criteria which allow a selection of patients with a good prognosis for topical immunotherapy with diphencyprone.The anamnestic and clinical data of 50 successfully and 55 unsuccessfully treated patients were compared by the Mann-Whitney test.Five factors were found to be of prognostic significance: type of AA (p < or = 0.001), presence of nail changes (p < or = 0.001), duration of AA before treatment (p < or = 0.005), age at onset (p < or = 0.01) and association with atopic eczema (p < or = 0.02).A selection of AA patients who are likely to respond to topical immunotherapy is possible on the basis of anamnestic and clinical data.
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