肌红蛋白
能源景观
产量(工程)
一氧化碳
化学
基础(线性代数)
简单(哲学)
蛋白质动力学
化学物理
统计物理学
物理
分子动力学
计算化学
生物系统
热力学
生物
数学
认识论
哲学
几何学
生物化学
催化作用
作者
Hans Frauenfelder,Stephen G. Sligar,Peter G. Wolynes
出处
期刊:Science
[American Association for the Advancement of Science]
日期:1991-12-13
卷期号:254 (5038): 1598-1603
被引量:3136
标识
DOI:10.1126/science.1749933
摘要
Recent experiments, advances in theory, and analogies to other complex systems such as glasses and spin glasses yield insight into protein dynamics. The basis of the understanding is the observation that the energy landscape is complex: Proteins can assume a large number of nearly isoenergetic conformations (conformational substates). The concepts that emerge from studies of the conformational substates and the motions between them permit a quantitative discussion of one simple reaction, the binding of small ligands such as carbon monoxide to myoglobin.
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