突触修剪
小胶质细胞
神经科学
大脑发育
生物
免疫学
炎症
作者
Rosa Chiara Paolicelli,Giulia Bolasco,Francesca Pagani,Laura Maggi,Maria Scianni,Patrizia Panzanelli,Maurizio Giustetto,Tiago Alves Ferreira,Eva Guiducci,Laura Dumas,Davide Ragozzino,Cornelius Gross
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2011-09-09
卷期号:333 (6048): 1456-1458
被引量:3139
标识
DOI:10.1126/science.1202529
摘要
Microglia are highly motile phagocytic cells that infiltrate and take up residence in the developing brain, where they are thought to provide a surveillance and scavenging function. However, although microglia have been shown to engulf and clear damaged cellular debris after brain insult, it remains less clear what role microglia play in the uninjured brain. Here, we show that microglia actively engulf synaptic material and play a major role in synaptic pruning during postnatal development in mice. These findings link microglia surveillance to synaptic maturation and suggest that deficits in microglia function may contribute to synaptic abnormalities seen in some neurodevelopmental disorders.
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