二酮哌嗪
化学
立体选择性
离子液体
冷凝
氨基酸
有机化学
反应条件
组合化学
过滤(数学)
催化作用
数学
生物化学
热力学
统计
物理
作者
Manuel Jainta,Martin Nieger,Stefan Bräse
标识
DOI:10.1002/ejoc.200800605
摘要
Abstract The facile condensation of unprotected amino acids by a phosphite‐promoted one‐step coupling reaction is a highly efficient synthesis to generate stereoselective and optically pure symmetrical and unsymmetrical functionalized diketopiperazines. The use of microwaves enhanced by small amounts of ionic liquid is accompanied by significant improvement in reaction times and yields. Simple filtration through a pad of silica provides the pure compounds in very good to excellent yields.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
科研通智能强力驱动
Strongly Powered by AbleSci AI