小RNA
发病机制
生物
基因表达
非翻译区
基因表达调控
脊髓损伤
三素数非翻译区
微阵列
脊髓
生物信息学
基因
微阵列分析技术
细胞生物学
信使核糖核酸
神经科学
医学
遗传学
免疫学
作者
Nai-Kui Liu,Xiaofei Wang,Qing Bo Lu,Xiao Ming Xu
标识
DOI:10.1016/j.expneurol.2009.06.015
摘要
MicroRNAs (miRNAs) are a novel class of small non-coding RNAs that negatively regulate gene expression at the posttranscriptional level by binding to the 3' untranslated region of target mRNAs leading to their translational inhibition or sometimes degradation. We uncovered a previously unknown alteration in temporal expression of a large set of miRNAs following a contusive spinal cord injury (SCI) in adult rats using microarray analysis. These altered miRNAs can be classified into 3 categories: (1) up-regulation, (2) down-regulation and (3) an early up-regulation at 4 h followed by down-regulation at 1 and 7 days post-SCI. The bioinformatics analysis indicates that the potential targets for miRNAs altered after SCI include genes encoding components that are involved in the inflammation, oxidation, and apoptosis that are known to play important roles in the pathogenesis of SCI. These findings suggest that abnormal expression of miRNAs may contribute to the pathogenesis of SCI and are potential targets for therapeutic interventions following SCI.
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