Total Synthesis of (±)-Smenospondiol by Titanium(III)-Mediated Tandem Radical Cyclization

All articles of this category We describe the total synthesis of (±)-smenospondiol ( 1 ). Stereoselective construction of the drimane skeleton was accomplished by titanium(III)-mediated tandem radical cyclization of epoxide 9 . Non-polar solvent is essential for the success of the tandem cyclization. tandem radical cyclizations - titanium - sesquiterpene hydroquinones - smenospondiol - drimane skeletons