烟酰胺
剂型
化学
色谱法
布洛芬
活性成分
药物输送
药品
桂利嗪
药理学
有机化学
烟酰胺
医学
酶
作者
Yong-Dan Tang,Subbu S. Venkatraman,Freddy Boey,Liwei Wang
标识
DOI:10.1016/j.ijpharm.2006.11.060
摘要
Floating dosage forms enable the sustained delivery of drugs in the gastro-intestinal tract. In this study, a type of multi-unit floating gel bead was synthesized with calcium alginate, sunflower oil, and a drug of interest through an emulsification/gelation process. The alginate beads with oil addition were able to continuously float over the medium for 24 h under constant agitation while the non-oily beads could not. Three kinds of drugs with different hydrophilicities, ibuprofen, niacinamide and metoclopramide HCl, were tested in the study. The hydrophobic drug ibuprofen was released in a sustained manner for 24 h, due to the oil partitioning. With suitable modification, the beads were able to also release the hydrophilic drugs, niacinamide and metoclopramide HCl, for a similar duration. Therefore a floating dosage form that is able to sustain release both hydrophobic and hydrophilic drugs within its extended gastric retention time has been developed.
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