取代基
催化作用
卤化物
芳基
化学
戒指(化学)
硅烷化
硼
组合化学
金属
药物化学
有机化学
烷基
作者
Liam T. Ball,Guy C. Lloyd‐Jones,Christopher A. Russell
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2012-09-28
卷期号:337 (6102): 1644-1648
被引量:350
标识
DOI:10.1126/science.1225709
摘要
Gently Coupled Linked aryl rings are found in a broad range of commercial chemical products. Currently, the most versatile synthetic route to this motif involves cross-coupling of one ring with a halide substituent to another ring with a boron or metal-based substituent. Recent research has focused on eliminating the need for one or both of these activating substituents, but for the most part, the emerging methods have required high temperatures and high concentrations of one coupling partner. Ball et al. (p. 1644 ) now present a gold catalyst that can couple silyl-activated arenes to unactivated arenes in comparable concentrations at room temperature.
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