pH-modulating binary hydrogen-bonded organic frameworks accelerate diabetic wound healing

Diabetic foot ulcers have become an increasingly serious clinical problem, in which wound pH dysregulation and infection lead to impaired healing. To improve this situation, we propose a fabric coated with a binary hydrogen-bonded organic framework (SMU-8@W) to enhance wound healing efficiency. Specifically, the hydrogen-bonded organic framework (SMU-8) not only suppresses wound infection through its high photodynamic activity but also guides a "near-neutral-weakly acidic-near-neutral" pH transition at the wound site, thereby modulating the wound microenvironment. Moreover, SMU-8@W exhibits favorable hemostatic performance (BCI = 21.19 ± 2.52%), moisture permeability (5874.20 ± 196.03 g·m⁻²·d⁻¹), biosafety, and long-term stability, effectively managing wound exudate and alleviating inflammation, thereby accelerating wound healing. In summary, SMU-8@W offers a pH-modulating, infection-suppressing, angiogenesis-promoting, and collagen-enhancing therapeutic strategy for diabetic foot ulcers.