Caffeic acid restores the M1-polarized immune balance but decreases IgG and IgM levels in human colorectal cancer HT-29 cell-bearing nude mice

< 0.05) increased the TNF-α/IL-10 cytokine secretion ratio compared to that in the DC group, evidencing that low-dose CA administration reversed the immune response toward the M1-polarized immune balance in the HT-29 cell-bearing mice. CA administration may restore the M1-polarized immune balance but decrease serum IgG and IgM levels in subjects with colorectal cancer cells.