Hic et Runx: new insights into T cell tissue residency

Tissue-resident memory T cells (Trm), which typically do not enter the blood or lymphatic circulation at steady-state, are considered crucial for controlling pathogen entry at skin and mucosal barriers. Two recent studies (Fonseca . and Crowl .) shed light on the mechanisms of Trm cell differentiation. Tissue-resident memory T cells (Trm), which typically do not enter the blood or lymphatic circulation at steady-state, are considered crucial for controlling pathogen entry at skin and mucosal barriers. Two recent studies (Fonseca . and Crowl .) shed light on the mechanisms of Trm cell differentiation.