有机硅
对映选择合成
硅烷化
手性(物理)
过渡金属
化学
分子
催化作用
纳米技术
材料科学
组合化学
有机化学
物理
手征对称破缺
量子力学
Nambu–Jona Lasinio模型
夸克
作者
Yicong Ge,Xingfen Huang,Jie Ke,Chuan He
出处
期刊:Chem catalysis
[Elsevier]
日期:2022-11-01
卷期号:2 (11): 2898-2928
被引量:25
标识
DOI:10.1016/j.checat.2022.07.009
摘要
Organosilanes are important and valuable compounds that have found widespread applications in the fields of organic chemistry, agrochemistry, medicinal chemistry, and materials science. In modern synthetic chemistry, molecules featuring carbon−silicon bonds have attracted considerable interest given that these motifs can be efficiently converted to a wide range of functionalities. Among various approaches, transition-metal-catalyzed C−H silylation has emerged as a powerful tool for the synthesis of silicon-containing functional molecules, which has profoundly accelerated the iteration of organosilicon science. Despite the rapid development of C−H silylation, the enantioselective version of this elegant methodology was not known until 2013. In this review, we aim to summarize recent advances in the area of enantioselective C−H silylation mediated by chiral transition-metal catalysts, organized by the different forms of chirality of the enantioenriched organosilanes. We highlight the great potential of this methodology and intend to inspire further research and applications in this emerging area.
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