Ultrasensitive detection of methamphetamine by antibody-modified transistor assay

Abstract Effective detection of methamphetamine (Met) requires a fast, sensitive, and cheap testing assay. However, commercially available methods require expensive instruments and highly trained operators, which are time-consuming and labor-intensive. Herein, an antibody-modified graphene transistor assay is developed for sensitive and minute-level detection of Met in complex environments. The anti-Met probe captured charged targets within 120 s, leading to a p-doping effect near the graphene channel. The limit of detection reaches 50 aM (5.0 × 10 −17 M) Met in solution. The graphene transistor would be a valuable tool for Met detection effective prevention of drug abuse.