SSK1‐Loaded Neurotransmitter‐Derived Nanoparticles for Alzheimer's Disease Therapy via Clearance of Senescent Cells (Small 26/2024)

Alzheimer's Disease Therapy SSK1-NPs efficiently delivered SSK1 into the brain, at where SSK1 is specifically cleaved by β-galactosidase, which in turn induces the apoptosis of senescent cells. Treatment of SSK1-NP induced apoptosis of senescence cells in the brain and improved cognitive function and memory in aged Alzheimer's disease mice. More in article number 2308574, Jian Zhang, Yi Luo, Yan Liu, Jie Gao, You Yin, and co-workers.