纳米载体
免疫原性
免疫疗法
免疫系统
纳米技术
抗原
癌症免疫疗法
纳米囊
材料科学
医学
免疫学
药物输送
纳米颗粒
作者
Lanqun Mao,Panqin Ma,Xi Luo,Hongwei Cheng,Zhanxiang Wang,Enyi Ye,Xian Jun Loh,Yun Wu,Yupeng Liu
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-05-19
卷期号:17 (11): 9826-9849
被引量:9
标识
DOI:10.1021/acsnano.3c02273
摘要
The development of nanovaccines that employ polymeric delivery carriers has garnered substantial interest in therapeutic treatment of cancer and a variety of infectious diseases due to their superior biocompatibility, lower toxicity and reduced immunogenicity. Particularly, stimuli-responsive polymeric nanocarriers show great promise for delivering antigens and adjuvants to targeted immune cells, preventing antigen degradation and clearance, and increasing the uptake of specific antigen-presenting cells, thereby sustaining adaptive immune responses and improving immunotherapy for certain diseases. In this review, the most recent advances in the utilization of stimulus-responsive polymer-based nanovaccines for immunotherapeutic applications are presented. These sophisticated polymeric nanovaccines with diverse functions, aimed at therapeutic administration for disease prevention and immunotherapy, are further classified into several active domains, including pH, temperature, redox, light and ultrasound-sensitive intelligent nanodelivery systems. Finally, the potential strategies for the future design of multifunctional next-generation polymeric nanovaccines by integrating materials science with biological interface are proposed.
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