生物医学
基因组
生物
计算生物学
基因组编辑
人类基因组
基因
基因组组织
遗传学
作者
Eugenia A. Tiukacheva,Sergey V. Ulianov,Anna Karpukhina,S. V. Razin,Yegor Vassetzky
标识
DOI:10.1016/j.ymthe.2023.02.005
摘要
The human genome is folded into a multi-level 3D structure that controls many nuclear functions including gene expression. Recently, alterations in 3D genome organization were associated with several genetic diseases and cancer. As a consequence, experimental approaches are now being developed to modify the global 3D genome organization and that of specific loci. Here, we discuss emerging experimental approaches of 3D genome editing that may prove useful in biomedicine.
科研通智能强力驱动
Strongly Powered by AbleSci AI