卵泡膜
卵泡发生
生物
卵巢
人口
卵巢早衰
细胞生物学
内科学
内分泌学
医学
胚胎
环境卫生
低温保存
作者
Hanne Vlieghe,Ellen Cristina Rivas Leonel,Parinaz Asiabi,Christiani Andrade Amorim
出处
期刊:Life Sciences
[Elsevier]
日期:2023-03-01
卷期号:317: 121479-121479
被引量:1
标识
DOI:10.1016/j.lfs.2023.121479
摘要
Theca cells perform a range of roles during folliculogenesis. So far, little is known about their recruitment process and function since early research has mainly focused on the interactions between granulosa cells and the oocyte, leaving theca cells unfairly forgotten in the understanding of ovarian physiology and pathogenesis. Given that research on theca cells has greatly emerged in recent years, this review of literature aims to discuss the established theoretical concepts with the most recent findings about theca cells' characterization and origins, in vitro culture applications as models for fertility preservation and pharmacological/toxicological studies, its importance in unraveling pathogenic pathways, and stem-cell-based bioengineering for hormonal replacement therapies. Isolation and in vitro culture techniques for theca cells have led to essential advancements in their characterization as a specific cell population. Unraveling the origins of theca cells during the in vivo differentiation process in the adult ovary will assist the development of hormonal replacement therapies, reestablishment of fertility, and treatments for diseases such as premature ovarian insufficiency and polycystic ovarian syndrome, which seem to be directly influenced by theca cells.
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